Project “CanBioSe - Novel 1D photonic metal oxide nanostructures for early stage cancer detection.”
Project coordinator:
LATVIJAS UNIVERSITATE/ UNIVERSITY OF LATVIA/ Latvia
Partners:
VILNIAUS UNIVERSITETAS/ Lithuania
ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER/ France
UNIWERSYTET IM. ADAMA MICKIEWICZA W POZNANIU/ Poland
FONDAZIONE BRUNO KESSLER/ Italy
EESTI MATERJALITEHNOLOOGIATE ARENDUSKESKUSE AS/ Estonia
BIOSENSOR S.R.L./ Italy
NANOPHARMA AS/ Czech Republic
NANO PRIME SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA/ Poland
MATERIALS RESEARCH CENTER/ Ukraine
CSD HEALTH CARE/ Ukraine
SENSOGRAFA/ Lithuania
3D STRONG/ Latvia
CanBioSe – A project that will help with early cancer detection
The project research and innovation goals are targeted to develop a new portable tool for early stage cancer detection which can solve one of the important health challenges in EU society. The CanBioSe project is targeted to strengthen international and intersectoral collaboration, sharing new ideas, knowledge transfer from research to market, and vice versa in the field of nanostructured metal oxide optical biosensors for cancer cell detection.
More than just research:
The project partners will provide research and training activities in the fields of nanotechnology, surface functionalization, bioengineering, microfluidics and biosensor testing, market analysis and commercialization. The provided research and management training to experienced researchers and early stage researchers will be quite beneficial. It will strengthen their personal skills and CVs via the new scientific papers and conference theses and strengthen a development of EU research human resources. We foresee a long lasting collaboration between the partners, based on co-supervising students and the preparation of novel collaborative project proposals. Also foreseen is a dissemination of the project results to the scientific society and wide auditories.
Scientific work will include:
One dimensional (1D) polimer nanofibers will be deposited by an electrospinning technique. Photonic nanomaterials, based on metal oxide based nanostructures (ZnO, ZnO/Al2O3 nanolaminates, Au/ZnO and ZnO/Au) will coat the 1D nanofibers. Metal oxides and Au nanoparticles will be deposited with Atomic Layer Deposition (ALD) and electrophoresis, respectively. Bioselective layer will be formed by immobilization of specific antibodies on the biosensor surface. Photoluminescence and optical spectroscopy will be used for recording the biosensor signal. Biosensor testing will be performed on cancer cells (human chronic lymphocyte leukemia (CLL) leucosis and acute lymphoblastic leucosis). The biosensor will be integrated with microfluidic system in order to minimize dimensions and simplify the use of the detection system.